Publications

Vascular Endothelial Cell Behavior in Complex Mechanical Microenvironments

The endothelium experiences a combination of interrelated hemodynamic forces from fluid flow, lateral pressure, cyclic stretch, and vessel wall forces from the mechanical (elastic and viscoelastic) and topographical properties of the extracellular matrix.

https://doi.org/10.1021/acsbiomaterials.8b00628  

Altered Functions of Human Blood-Derived Vascular Endothelial Cells by Simulated Microgravity

The goal of this study was to understand the effects of simulated microgravity on the proliferative, secretory, and anti-thrombogenic functions of endothelial cells differentiated from human blood-derived progenitor cells. 

https://doi.org/10.2478/gsr-2016-0001 

Sex-Specific Response to Combinations of Shear Stress and Substrate Stiffness by Endothelial Cells In Vitro

The work presented highlights the differential response of male and female endothelial cells to microenvironments of physiological shear stress and substrates stiffness. Conditions where male endothelial cells showed sensitivity to mechanical stimulation, female endothelial cells were largely insensitive. 

doi.org/10.1002/adhm.202170084