DNA Based Technologies

DNA Aptamer Technology

DNA-Collagen based fibrous Biomaterials

The Allen lab is interested in the self-assembly of single-stranded DNA (ssDNA) and collagen. Termed Nucleic Acid-Collagen Complexes (NACCs), we are exploring their material properties and promising bioactivity, particularly with aptamer-specific ssDNA oligonucleotides. Existing work suggests NACC-induced cell signaling applications in bone tissue engineering and angiogenic-like endothelial cell phenotypes.

Publications on this topic

Anti‐VEGF‐R2 Aptamer and RGD Peptide Synergize in a Bifunctional Hydrogel for Enhanced Angiogenic Potential. Macromolecular Bioscience. Nov 2020.
Self-assembled VEGF-R2 targeting DNA aptamer-collagen fibers stimulate an angiogenic-like endothelial cell phenotype. Materials Science & Engineering: C. Oct 2020.
DNA Aptamer Assembly as a Vascular Endothelial Growth Factor Receptor Agonist. Nucleic Acid Therapeutics 2015 Oct; 25(5):227-34.

Publications on this topic

Exploring the Fibrous Nature of Single-Stranded DNA-Collagen Complexes: Nanostructural Observations and Physicochemical Insights. ACS Omega, July 2024.
Toward Bioactive Hydrogels: A Tunable Approach via Nucleic Acid-Collagen Complexation. Regen. Eng. & Transl. Med, May 2024.
Mineralized DNA-collagen complex-based biomaterials for bone tissue engineering. (June 2020) International Journal of Biological Macromolecules. Oct 2020, Volume 161, Pages 1127-1139
Oligomer length defines the self-assembly of single stranded DNA-collagen complex fibers. ACS Biomaterials Science & Engineering. Jan 2020, 6, 1, 213-218

Funding

We are grateful for support for this work from the following sources:

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